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Background
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This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BM28, CCNL1, CDCL1, D3S3194, KIAA0030, MGC10606, MITOTIN, cdc19
Protein Interaction Partner: MCM3,MCM3,MCM5,MCM5,MCM6,MCM6,AKAP8,CCNB2,CDC6,CDC7,CDK4,CDK6,CDKN2A,CPSF1,DBF4,GNB5,GTF2B,GTF2H1,HIST3H3,MCM10,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MOBKL3,MPP3,MYST2,ORC1L,ORC2L,ORC4L,ORC5L,ORC6L,PHC2,PLK1,RAD52,RPA1,RPA2,RPA3,RPS4X,TBP,AIRE,AKAP8,ATM,ATR,BRCC3,CCNC,CDC7,DBF4,GNB5,ING5,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MOBKL3,MPP3,ORC1L,ORC2L,ORC4L,ORC5L,PHC2,RPA1,RPA2,RPA3,RPS4X,TBP,TCEA2
Protein Size: 904
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